INDOLEAMINE ANTAGONISTS: RELATIVE POTENCIES AS INHIBITORS OF TRYPTAMINE- AND 5-HYDROXYTRYPTOPHAN-EVOKED RESPONSES
نویسندگان
چکیده
منابع مشابه
Relative potencies of antagonists of the luteinizing hormone releasing hormone with Lys8 and Arg8 and substitutions in positions 3, 5, 6, 7 and 8.
Antagonists of the luteinizing hormone releasing hormone (LHRH) of increased potency is a goal for control of ovulation. In the design and synthesis of 26 decapeptides, emphasis was given to analogs with Lys8 and Arg8 and with various substitutions in positions 3, 5, 6, 7 and 8. Two antagonists, [N-Ac-D-2-Nal1,D-pClPhe2,D-3-Pal3,Ser4,Tyr5,D-Ar g6,Leu7,Lys8, Pro9,D-Ala10]-NH2 and [N-Ac-D-2-Nal1,...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1974
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1974.tb08577.x